Our group is studying head/neck cancer, pancreatic cancer and Sjogren's syndrome using proteomics, with a focus on understanding the molecular mechanisms of diseases and developing diagnostic/therapeutic applications. Using mass spectrometry and protein microarray technology, we have discovered target proteins involved in malignant transformation and tumor metastasis of head/neck and pancreatic cancers. We are interested in immunoproteasome in Sjogren's syndrome as well as single cell proteomics and related applications in stem cell and developmental biology.
Project 1: Oral precancer and cancer proteomics
Project 2: Immunoproteasome in Sjogren's syndrome
Project 3: Development of a tracer-based metabolomics methodology for studying pancreatic cancer
Project 4: Single cell analysis and cancer stem cell biology
